Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR

Specific arrestin conformations are coupled to distinct downstream effectors, which underlie the functions of many G-protein-coupled receptors (GPCRs). Here, using unnatural amino acid incorporation and fluorine-19 nuclear magnetic resonance ((19)F-NMR) spectroscopy, we demonstrate that distinct rec...

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Publicado no:Nat Commun
Main Authors: Yang, Fan, Yu, Xiao, Liu, Chuan, Qu, Chang-Xiu, Gong, Zheng, Liu, Hong-Da, Li, Fa-Hui, Wang, Hong-Mei, He, Dong-Fang, Yi, Fan, Song, Chen, Tian, Chang-Lin, Xiao, Kun-Hong, Wang, Jiang-Yun, Sun, Jin-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569848/
https://ncbi.nlm.nih.gov/pubmed/26347956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9202
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