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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

Humans are chronically exposed to multiple exogenous substances, including environmental pollutants, drugs and dietary components. Many of these compounds are suspected to impact human health, and their combination in complex mixtures could exacerbate their harmful effects. Here we demonstrate that...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Delfosse, Vanessa, Dendele, Béatrice, Huet, Tiphaine, Grimaldi, Marina, Boulahtouf, Abdelhay, Gerbal-Chaloin, Sabine, Beucher, Bertrand, Roecklin, Dominique, Muller, Christina, Rahmani, Roger, Cavaillès, Vincent, Daujat-Chavanieu, Martine, Vivat, Valérie, Pascussi, Jean-Marc, Balaguer, Patrick, Bourguet, William
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569708/
https://ncbi.nlm.nih.gov/pubmed/26333997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9089
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