A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays

The nuclear receptor pregnane X receptor (PXR) is a ligand-dependent transcription factor that regulates genes involved in xenobiotic metabolism in mammals. Many studies suggest that PXR may play a similar role in fish. The interaction of human PXR (hPXR) with a variety of structurally diverse endog...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Creusot, Nicolas, Garoche, Clémentine, Grimaldi, Marina, Boulahtouf, Abdelhay, Chiavarina, Barbara, Bourguet, William, Balaguer, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8167039/
https://ncbi.nlm.nih.gov/pubmed/34084152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2021.665521
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