Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

Humans are chronically exposed to multiple exogenous substances, including environmental pollutants, drugs and dietary components. Many of these compounds are suspected to impact human health, and their combination in complex mixtures could exacerbate their harmful effects. Here we demonstrate that...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Delfosse, Vanessa, Dendele, Béatrice, Huet, Tiphaine, Grimaldi, Marina, Boulahtouf, Abdelhay, Gerbal-Chaloin, Sabine, Beucher, Bertrand, Roecklin, Dominique, Muller, Christina, Rahmani, Roger, Cavaillès, Vincent, Daujat-Chavanieu, Martine, Vivat, Valérie, Pascussi, Jean-Marc, Balaguer, Patrick, Bourguet, William
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569708/
https://ncbi.nlm.nih.gov/pubmed/26333997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9089
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