The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

The human pregnane X receptor (hPXR) is activated by a large set of endogenous and exogenous compounds and plays a critical role in the control of detoxifying enzymes and transporters regulating liver and gastrointestinal drug metabolism and clearance. hPXR is also involved in both the development o...

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Publicado no:Cells
Main Authors: Creusot, Nicolas, Gassiot, Matthieu, Alaterre, Elina, Chiavarina, Barbara, Grimaldi, Marina, Boulahtouf, Abdelhay, Toporova, Lucia, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Matheux, Alice, Rahmani, Roger, Gongora, Céline, Evrard, Alexandre, Pourquier, Philippe, Balaguer, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407672/
https://ncbi.nlm.nih.gov/pubmed/32650447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071641
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