The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

The human pregnane X receptor (hPXR) is activated by a large set of endogenous and exogenous compounds and plays a critical role in the control of detoxifying enzymes and transporters regulating liver and gastrointestinal drug metabolism and clearance. hPXR is also involved in both the development o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cells
Prif Awduron: Creusot, Nicolas, Gassiot, Matthieu, Alaterre, Elina, Chiavarina, Barbara, Grimaldi, Marina, Boulahtouf, Abdelhay, Toporova, Lucia, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Matheux, Alice, Rahmani, Roger, Gongora, Céline, Evrard, Alexandre, Pourquier, Philippe, Balaguer, Patrick
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407672/
https://ncbi.nlm.nih.gov/pubmed/32650447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071641
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