Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non-cell autonomously to rod photoreceptor degeneration by primary phagocytosis of living rods. Using rd10 mice, we found that the in...

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Bibliografiske detaljer
Udgivet i:EMBO Mol Med
Main Authors: Zhao, Lian, Zabel, Matthew K, Wang, Xu, Ma, Wenxin, Shah, Parth, Fariss, Robert N, Qian, Haohua, Parkhurst, Christopher N, Gan, Wen-Biao, Wong, Wai T
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2015
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568951/
https://ncbi.nlm.nih.gov/pubmed/26139610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505298
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