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7-Ketocholesterol Increases Retinal Microglial Migration, Activation, and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration

Age-related macular degeneration (AMD) has been associated with both accumulation of lipid and lipid oxidative products, as well as increased neuroinflammatory changes and microglial activation in the outer retina. However, the relationships between these factors are incompletely understood. 7-Ketoc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Indaram, Maanasa, Ma, Wenxin, Zhao, Lian, Fariss, Robert N., Rodriguez, Ignacio R., Wong, Wai T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360733/
https://ncbi.nlm.nih.gov/pubmed/25775051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09144
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