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A2E accumulation influences retinal microglial activation and complement regulation

Age-related macular degeneration (AMD) is an outer retinal disease that involves aging and immune dysfunction. In the aging retina, microglia aggregate in the outer retina and acquire intracellular autofluorescent lipofuscin deposits. In this study, we investigated whether accumulation of A2E, a key...

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Hlavní autoři: Ma, Wenxin, Coon, Steven, Zhao, Lian, Fariss, Robert N., Wong, Wai T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480997/
https://ncbi.nlm.nih.gov/pubmed/22819137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.06.010
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