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Abrogation of Airway Hyperresponsiveness but not Inflammation by Rho kinase Insufficiency

BACKGROUND: Major features of allergic asthma include airway hyperresponsiveness (AHR), eosinophilic inflammation, and goblet cell metaplasia. Rho kinase (ROCK) is a serine/threonine protein kinase that regulates the actin cytoskeleton. By doing so, it can modulate airway smooth muscle cell contract...

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Publicat a:Clin Exp Allergy
Autors principals: Kasahara, David I., Ninin, Fernanda M.C., Wurmbrand, Allison P., Liao, James K., Shore, Stephanie A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568824/
https://ncbi.nlm.nih.gov/pubmed/25323425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.12438
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