Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic inflammation of synovial joints, ultimately leading to a progressive and irreversible joint destruction. Activation of nuclear factor-kappa B (NF-κB) promotes production of proinflammatory cytokines in various inflammator...

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Vydáno v:Am J Transl Res
Hlavní autoři: Tsubaki, Masanobu, Takeda, Tomoya, Kino, Toshiki, Itoh, Tatsuki, Imano, Motohiro, Tanabe, Genzo, Muraoka, Osamu, Satou, Takao, Nishida, Shozo
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568793/
https://ncbi.nlm.nih.gov/pubmed/26396668
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