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Structure of an intermediate conformer of the spindle checkpoint protein Mad2

The spindle checkpoint senses unattached kinetochores during prometaphase and inhibits the anaphase-promoting complex or cyclosome (APC/C), thus ensuring accurate chromosome segregation. The checkpoint protein mitotic arrest deficient 2 (Mad2) is an unusual protein with multiple folded states. Mad2...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hara, Mayuko, Özkan, Engin, Sun, Hongbin, Yu, Hongtao, Luo, Xuelian
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568698/
https://ncbi.nlm.nih.gov/pubmed/26305957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512197112
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