Velocities of unloaded muscle filaments are not limited by drag forces imposed by myosin cross-bridges

It is not known which kinetic step in the acto-myosin ATPase cycle limits contraction speed in unloaded muscles (V(0)). Huxley’s 1957 model [Huxley AF (1957) Prog Biophys Biophys Chem 7:255–318] predicts that V(0) is limited by the rate that myosin detaches from actin. However, this does not explain...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Brizendine, Richard K., Alcala, Diego B., Carter, Michael S., Haldeman, Brian D., Facemyer, Kevin C., Baker, Josh E., Cremo, Christine R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568697/
https://ncbi.nlm.nih.gov/pubmed/26294254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510241112
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