Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle

Smooth muscle myosin (SMM) light chain kinase (MLCK) phosphorylates SMM, thereby activating the ATPase activity required for muscle contraction. The abundance of active MLCK, which is tightly associated with the contractile apparatus, is low relative to that of SMM. SMM phosphorylation is rapid desp...

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Udgivet i:J Gen Physiol
Main Authors: Hong, Feng, Brizendine, Richard K., Carter, Michael S., Alcala, Diego B., Brown, Avery E., Chattin, Amy M., Haldeman, Brian D., Walsh, Michael P., Facemyer, Kevin C., Baker, Josh E., Cremo, Christine R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586593/
https://ncbi.nlm.nih.gov/pubmed/26415568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511483
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