Propagation of prions causing synucleinopathies in cultured cells

Increasingly, evidence argues that many neurodegenerative diseases, including progressive supranuclear palsy (PSP), are caused by prions, which are alternatively folded proteins undergoing self-propagation. In earlier studies, PSP prions were detected by infecting human embryonic kidney (HEK) cells...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568231/
https://ncbi.nlm.nih.gov/pubmed/26286986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513426112
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