Propagation of prions causing synucleinopathies in cultured cells

Increasingly, evidence argues that many neurodegenerative diseases, including progressive supranuclear palsy (PSP), are caused by prions, which are alternatively folded proteins undergoing self-propagation. In earlier studies, PSP prions were detected by infecting human embryonic kidney (HEK) cells...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568231/
https://ncbi.nlm.nih.gov/pubmed/26286986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513426112
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