Loss of marginal zone B-cells in SHIV(SF162P4) challenged Rhesus macaques despite control of viremia to low or undetectable levels in chronic infection

Marginal zone (MZ) B cells generate T-independent antibody responses to pathogens before T-dependent antibodies arise in germinal centers. They have been identified in cynomolgus monkeys and monitored during acute SIV infection, yet have not been well-studied in rhesus macaques. Here we characterize...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Demberg, Thorsten, Mohanram, Venkatramanan, Musich, Thomas, Brocca-Cofano, Egidio, McKinnon, Katherine M., Venzon, David, Robert-Guroff, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567457/
https://ncbi.nlm.nih.gov/pubmed/26151223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.06.022
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