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Redoxal, an Inhibitor of De Novo Pyrimidine Biosynthesis, Augments APOBEC3G Antiviral Activity Against Human Immunodeficiency Virus Type 1
APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA; deamination-independent mechanisms are also implicated. HIV-1 Vif protein counteracts A3G by inducing its proteasomal degradation. Thus, the Vif-A3G axis is a potential therapeutic...
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| Publicat a: | Virology |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4567410/ https://ncbi.nlm.nih.gov/pubmed/26141568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.06.014 |
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