Redoxal, an Inhibitor of De Novo Pyrimidine Biosynthesis, Augments APOBEC3G Antiviral Activity Against Human Immunodeficiency Virus Type 1

APOBEC3G (A3G) is a cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA; deamination-independent mechanisms are also implicated. HIV-1 Vif protein counteracts A3G by inducing its proteasomal degradation. Thus, the Vif-A3G axis is a potential therapeutic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Virology
Prif Awduron: Pery, Erez, Sheehy, Ann, Nebane, N. Miranda, Misra, Vikas, Mankowski, Marie K., Rasmussen, Lynn, White, E. Lucile, Ptak, Roger G., Gabuzda, Dana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567410/
https://ncbi.nlm.nih.gov/pubmed/26141568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.06.014
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