Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein

APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA and by deamination-independent mechanisms. HIV-1 Vif binds to A3G, resulting in its degradation via the 26 S proteasome. Therefore, this interaction represents a potential t...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Pery, Erez, Sheehy, Ann, Nebane, N. Miranda, Brazier, Andrew Jay, Misra, Vikas, Rajendran, Kottampatty S., Buhrlage, Sara J., Mankowski, Marie K., Rasmussen, Lynn, White, E. Lucile, Ptak, Roger G., Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400358/
https://ncbi.nlm.nih.gov/pubmed/25724652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.626903
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