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Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling

Discovery of efficient anti-cancer drug combinations is a major challenge, since experimental testing of all possible combinations is clearly impossible. Recent efforts to computationally predict drug combination responses retain this experimental search space, as model definitions typically rely on...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Flobak, Åsmund, Baudot, Anaïs, Remy, Elisabeth, Thommesen, Liv, Thieffry, Denis, Kuiper, Martin, Lægreid, Astrid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567168/
https://ncbi.nlm.nih.gov/pubmed/26317215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004426
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