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Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo

The use of irinotecan to treat metastatic colorectal cancer (CRC) is limited by unpredictable response and variable toxicity; however, no reliable clinical biomarkers are available. Here, we report a study to ascertain whether irinotecan-induced DNA damage measures are suitable/superior biomarkers o...

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Publicat a:Cancer Med
Autors principals: Wood, Joanna P, Smith, Andrew J O, Bowman, Karen J, Thomas, Anne L, Jones, George D D
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567016/
https://ncbi.nlm.nih.gov/pubmed/26108357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.477
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