Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13

We investigated the role of periostin, an extracellular matrix protein, in the pathophysiology of osteoarthritis (OA). In OA, dysregulated gene expression and phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the joint surface. The molecular mechanisms unde...

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Detaylı Bibliyografya
Yayımlandı:FASEB J
Asıl Yazarlar: Attur, Mukundan, Yang, Qing, Shimada, Kohei, Tachida, Yuki, Nagase, Hiroyuki, Mignatti, Paolo, Statman, Lauren, Palmer, Glyn, Kirsch, Thorsten, Beier, Frank, Abramson, Steven B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Federation of American Societies for Experimental Biology 2015
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566939/
https://ncbi.nlm.nih.gov/pubmed/26092928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272427
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