MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT

OBJECTIVES: To investigate the role of matrix metalloproteinase (MMP)-13/collagenase-3 in osteoarthritis (OA). METHODS: Surgically-induced OA in knees of MMP-13 knock out (KO) and wild type (WT) mice was compared. Femoral and tibial cartilage aggrecan loss (0–3), erosion (0–7) and chondrocyte hypert...

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Hlavní autoři: Little, CB, Barai, A, Burkhardt, D, Smith, SM, Fosang, AJ, Werb, Z, Shah, M, Thompson, EW.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832925/
https://ncbi.nlm.nih.gov/pubmed/19950295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.25002
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