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MATRIX METALLOPROTEINASE-13 DEFICIENT MICE ARE RESISTANT TO OSTEOARTHRITIC CARTILAGE EROSION BUT NOT CHONDROCYTE HYPERTROPHY OR OSTEOPHYTE DEVELOPMENT
OBJECTIVES: To investigate the role of matrix metalloproteinase (MMP)-13/collagenase-3 in osteoarthritis (OA). METHODS: Surgically-induced OA in knees of MMP-13 knock out (KO) and wild type (WT) mice was compared. Femoral and tibial cartilage aggrecan loss (0–3), erosion (0–7) and chondrocyte hypert...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832925/ https://ncbi.nlm.nih.gov/pubmed/19950295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.25002 |
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