Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13

We investigated the role of periostin, an extracellular matrix protein, in the pathophysiology of osteoarthritis (OA). In OA, dysregulated gene expression and phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the joint surface. The molecular mechanisms unde...

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Vydáno v:FASEB J
Hlavní autoři: Attur, Mukundan, Yang, Qing, Shimada, Kohei, Tachida, Yuki, Nagase, Hiroyuki, Mignatti, Paolo, Statman, Lauren, Palmer, Glyn, Kirsch, Thorsten, Beier, Frank, Abramson, Steven B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2015
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566939/
https://ncbi.nlm.nih.gov/pubmed/26092928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-272427
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