Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

Fibrinogen, coagulation factor VII (FVII), and factor VIII (FVIII) and its carrier von Willebrand factor (vWF) play key roles in hemostasis. Previously identified common variants explain only a small fraction of the trait heritabilities, and additional variations may be explained by associations wit...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Huffman, Jennifer E., de Vries, Paul S., Morrison, Alanna C., Sabater-Lleal, Maria, Kacprowski, Tim, Auer, Paul L., Brody, Jennifer A., Chasman, Daniel I., Chen, Ming-Huei, Guo, Xiuqing, Lin, Li-An, Marioni, Riccardo E., Müller-Nurasyid, Martina, Yanek, Lisa R., Pankratz, Nathan, Grove, Megan L., de Maat, Moniek P. M., Cushman, Mary, Wiggins, Kerri L., Qi, Lihong, Sennblad, Bengt, Harris, Sarah E., Polasek, Ozren, Riess, Helene, Rivadeneira, Fernando, Rose, Lynda M., Goel, Anuj, Taylor, Kent D., Teumer, Alexander, Uitterlinden, André G., Vaidya, Dhananjay, Yao, Jie, Tang, Weihong, Levy, Daniel, Waldenberger, Melanie, Becker, Diane M., Folsom, Aaron R., Giulianini, Franco, Greinacher, Andreas, Hofman, Albert, Huang, Chiang-Ching, Kooperberg, Charles, Silveira, Angela, Starr, John M., Strauch, Konstantin, Strawbridge, Rona J., Wright, Alan F., McKnight, Barbara, Franco, Oscar H., Zakai, Neil, Mathias, Rasika A., Psaty, Bruce M., Ridker, Paul M., Tofler, Geoffrey H., Völker, Uwe, Watkins, Hugh, Fornage, Myriam, Hamsten, Anders, Deary, Ian J., Boerwinkle, Eric, Koenig, Wolfgang, Rotter, Jerome I., Hayward, Caroline, Dehghan, Abbas, Reiner, Alex P., O’Donnell, Christopher J., Smith, Nicholas L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566813/
https://ncbi.nlm.nih.gov/pubmed/26105150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-624551
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