Generation and Preclinical Characterization of an NKp80-Fc Fusion Protein for Redirected Cytolysis of Natural Killer (NK) Cells against Leukemia

The capacity of natural killer (NK) cells to mediate Fc receptor-dependent effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), largely contributes to their clinical application. Given that activation-induced C-type lectin (AICL), an identified ligand for the NK-activating re...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Deng, Gang, Zheng, Xiaodong, Zhou, Jing, Wei, Haiming, Tian, Zhigang, Sun, Rui
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566223/
https://ncbi.nlm.nih.gov/pubmed/26198633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678912
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