Generation and Preclinical Characterization of a Fc-optimized GITR-Ig Fusion Protein for Induction of NK Cell Reactivity Against Leukemia

Natural killer (NK) cells are cytotoxic lymphocytes that largely contribute to the efficacy of therapeutic strategies like allogenic stem cell transplantation in acute myeloid leukemia (AML) and application of Rituximab in chronic lymphocytic leukemia (CLL). The tumor necrosis factor (TNF) family me...

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Detalhes bibliográficos
Main Authors: Schmiedel, Benjamin Joachim, Werner, Antje, Steinbacher, Julia, Nuebling, Tina, Buechele, Corina, Grosse-Hovest, Ludger, Salih, Helmut Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616539/
https://ncbi.nlm.nih.gov/pubmed/23380816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.11
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