YAP inhibition restores hepatocyte differentiation in advanced HCC leading to tumor regression

Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat maintaining metabolic specialization, differentiation and...

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Опубликовано в: :Cell Rep
Главные авторы: Fitamant, Julien, Kottakis, Filippos, Benhamouche, Samira, Tian, Helen S., Chuvin, Nicolas, Parachoniak, Christine A., Nagle, Julia M., Perera, Rushika M., Lapouge, Marjorie, Deshpande, Vikram, Zhu, Andrew X., Lai, Albert, Min, Bosun, Hoshida, Yujin, Avruch, Joseph, Sia, Daniela, Campreciós, Genís, McClatchey, Andrea I., Llovet, Josep M., Morrissey, David, Raj, Lakshmi, Bardeesy, Nabeel
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565791/
https://ncbi.nlm.nih.gov/pubmed/25772357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.027
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