Matrix Metalloproteinase-2 (MMP-2) Gene Deletion Enhances MMP-9 Activity, Impairs PARP-1 Degradation, and Exacerbates Hepatic Ischemia and Reperfusion Injury in Mice

Hepatic ischemia and reperfusion injury (IRI) is an inflammatory condition and a significant cause of morbidity and mortality after surgery. Matrix metalloproteinases (MMPs) have been widely implicated in the pathogenesis of inflammatory diseases. Among the different MMPs, gelatinases (MMP-2 and MMP...

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Veröffentlicht in:PLoS One
Hauptverfasser: Kato, Hiroyuki, Duarte, Sergio, Liu, Daniel, Busuttil, Ronald W., Coito, Ana J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565667/
https://ncbi.nlm.nih.gov/pubmed/26355684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137642
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