TISSUE INHIBITOR OF METALLOPROTEINASES-1 (TIMP-1) DEFICIENCY LEADS TO LETHAL PARTIAL HEPATIC ISCHEMIA AND REPERFUSION INJURY

Hepatic ischemia and reperfusion injury (IRI) remains an important challenge in clinical orthotopic liver transplantation (OLT). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the major endogenous regulator of matrix metalloproteinase-9 (MMP-9). In this study, we investigated the functional sig...

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Hauptverfasser: Duarte, Sergio, Hamada, Takashi, Kuriyama, Naohisa, Busuttil, Ronald W., Coito, Ana J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386467/
https://ncbi.nlm.nih.gov/pubmed/22407827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25710
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