Hepatic Ischemia and Reperfusion Injury in the Absence of Myeloid Cell-Derived COX-2 in Mice

Cyclooxygenase-2 (COX-2) is a mediator of hepatic ischemia and reperfusion injury (IRI). While both global COX-2 deletion and pharmacologic COX-2 inhibition ameliorate liver IRI, the clinical use of COX-2 inhibitors has been linked to increased risks of heart attack and stroke. Therefore, a better u...

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Detalhes bibliográficos
Main Authors: Duarte, Sergio, Kato, Hiroyuki, Kuriyama, Naohisa, Suko, Kathryn, Ishikawa, Tomo-o, Busuttil, Ronald W., Herschman, Harvey R., Coito, Ana J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018446/
https://ncbi.nlm.nih.gov/pubmed/24819536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096913
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