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Structural Dynamics and Thermostabilization of Neurotensin Receptor 1

[Image: see text] The neurotensin receptor NTSR1 binds the peptide agonist neurotensin (NTS) and signals preferentially via the G(q) protein. Recently, Grisshammer and co-workers reported the crystal structure of a thermostable mutant NTSR1-GW5 with NTS bound. Understanding how the mutations thermos...

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Pubblicato in:J Phys Chem B
Autori principali: Lee, Sangbae, Bhattacharya, Supriyo, Tate, Christopher G., Grisshammer, Reinhard, Vaidehi, Nagarajan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564841/
https://ncbi.nlm.nih.gov/pubmed/25807267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp510735f
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