Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice

Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis re...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Gabriel, Gülsah, Feldmann, Friederike, Reimer, Rudolph, Thiele, Swantje, Fischer, Meike, Hartmann, Enno, Bader, Michael, Ebihara, Hideki, Hoenen, Thomas, Feldmann, Heinz
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Ebola and Marburg Viruses-Research, Outbreak Management, Epidemiology and Ecology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564549/
https://ncbi.nlm.nih.gov/pubmed/26185094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv240
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