An Improved Reverse Genetics System to Overcome Cell-Type–Dependent Ebola Virus Genome Plasticity

Reverse genetics systems represent a key technique for studying replication and pathogenesis of viruses, including Ebola virus (EBOV). During the rescue of recombinant EBOV from Vero cells, a high frequency of mutations was observed throughout the genomes of rescued viruses, including at the RNA edi...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Tsuda, Yoshimi, Hoenen, Thomas, Banadyga, Logan, Weisend, Carla, Ricklefs, Stacy M., Porcella, Stephen F., Ebihara, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Ebola and Marburg Viruses-Research, Outbreak Management, Epidemiology and Ecology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564527/
https://ncbi.nlm.nih.gov/pubmed/25810440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu681
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