Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice

Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis re...

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Bibliografiska uppgifter
I publikationen:J Infect Dis
Huvudupphovsmän: Gabriel, Gülsah, Feldmann, Friederike, Reimer, Rudolph, Thiele, Swantje, Fischer, Meike, Hartmann, Enno, Bader, Michael, Ebihara, Hideki, Hoenen, Thomas, Feldmann, Heinz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Ebola and Marburg Viruses-Research, Outbreak Management, Epidemiology and Ecology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564549/
https://ncbi.nlm.nih.gov/pubmed/26185094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv240
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