S6K1 controls pancreatic β cell size independently of intrauterine growth restriction

Type 2 diabetes mellitus (T2DM) is a worldwide heath problem that is characterized by insulin resistance and the eventual loss of β cell function. As recent studies have shown that loss of ribosomal protein (RP) S6 kinase 1 (S6K1) increases systemic insulin sensitivity, S6K1 inhibitors are being pur...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Um, Sung Hee, Sticker-Jantscheff, Melanie, Chau, Gia Cac, Vintersten, Kristina, Mueller, Matthias, Gangloff, Yann-Gael, Adams, Ralf H., Spetz, Jean-Francois, Elghazi, Lynda, Pfluger, Paul T., Pende, Mario, Bernal-Mizrachi, Ernesto, Tauler, Albert, Tschöp, Matthias H., Thomas, George, Kozma, Sara C.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563673/
https://ncbi.nlm.nih.gov/pubmed/26075820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77030
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