Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

The mammalian target of rapamycin (mTOR) is a key component of a signaling pathway which integrates inputs from nutrients and growth factors to regulate cell growth. Recent studies demonstrated that mice harboring an ethylnitrosourea-induced mutation in the gene encoding mTOR die at embryonic day 12...

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Autors principals: Gangloff, Yann-Gaël, Mueller, Matthias, Dann, Stephen G., Svoboda, Petr, Sticker, Melanie, Spetz, Jean-Francois, Um, Sung Hee, Brown, Eric J., Cereghini, Silvia, Thomas, George, Kozma, Sara C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC522282/
https://ncbi.nlm.nih.gov/pubmed/15485918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9508-9516.2004
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