Llwytho...

Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain

The primary afferent nociceptor was used as a model system to study mechanisms of pain induced by chronic opioid administration. Repeated intradermal injection of the selective mu-opioid receptor (MOR) agonist DAMGO induced mechanical hyperalgesia and marked prolongation of prostaglandin E(2) (PGE(2...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Araldi, Dioneia, Ferrari, Luiz F., Levine, Jon D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563038/
https://ncbi.nlm.nih.gov/pubmed/26354917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1673-15.2015
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