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Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain

The primary afferent nociceptor was used as a model system to study mechanisms of pain induced by chronic opioid administration. Repeated intradermal injection of the selective mu-opioid receptor (MOR) agonist DAMGO induced mechanical hyperalgesia and marked prolongation of prostaglandin E(2) (PGE(2...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Araldi, Dioneia, Ferrari, Luiz F., Levine, Jon D.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563038/
https://ncbi.nlm.nih.gov/pubmed/26354917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1673-15.2015
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