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Role of GPCR (Mu-Opioid)-RTK (Epidermal Growth Factor) Crosstalk in Opioid-Induced Hyperalgesic Priming (Type II)
Repeated stimulation of mu-opioid receptors (MOR), by a MOR selective agonist DAMGO induces Type II priming, a form of nociceptor neuroplasticity, which has two components: opioid-induced hyperalgesia (OIH) and prolongation of prostaglandin-E(2) (PGE(2))-induced hyperalgesia. We report that intrathe...
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| Publicado no: | Pain |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5908744/ https://ncbi.nlm.nih.gov/pubmed/29447132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001155 |
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