Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope (Env) glycoprotein with specific cell surface receptors. Protective antiviral antibodies generated by passive or active immunization must prevent these interactions. Because the HIV-1 Env is highly variable,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Pegu, Amarendra, Yang, Zhi-yong, Boyington, Jeffrey C., Wu, Lan, Ko, Sung-Youl, Schmidt, Stephen D., McKee, Krisha, Kong, Wing-Pui, Shi, Wei, Chen, Xuejun, Todd, John-Paul, Letvin, Norman L., Huang, Jinghe, Nason, Martha C., Hoxie, James A., Kwong, Peter D., Connors, Mark, Rao, Srinivas S., Mascola, John R., Nabel, Gary J.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562469/
https://ncbi.nlm.nih.gov/pubmed/24990883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008992
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