Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

HIV-1 infection depends on effective viral entry mediated by the interaction of its envelope (Env) glycoprotein with specific cell surface receptors. Protective antiviral antibodies generated by passive or active immunization must prevent these interactions. Because the HIV-1 Env is highly variable,...

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Detaylı Bibliyografya
Yayımlandı:Sci Transl Med
Asıl Yazarlar: Pegu, Amarendra, Yang, Zhi-yong, Boyington, Jeffrey C., Wu, Lan, Ko, Sung-Youl, Schmidt, Stephen D., McKee, Krisha, Kong, Wing-Pui, Shi, Wei, Chen, Xuejun, Todd, John-Paul, Letvin, Norman L., Huang, Jinghe, Nason, Martha C., Hoxie, James A., Kwong, Peter D., Connors, Mark, Rao, Srinivas S., Mascola, John R., Nabel, Gary J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562469/
https://ncbi.nlm.nih.gov/pubmed/24990883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008992
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