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Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy
Cell survival depends on the maintenance of mitochondrial integrity controlled by a well-balanced interplay between anti- and pro-apoptotic B cell lymphoma 2 (Bcl2) family members. Given their frequent deregulation in human pathologies, including autoimmunity and cancer, significant research efforts...
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| 發表在: | FEBS J |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4562365/ https://ncbi.nlm.nih.gov/pubmed/25559680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13188 |
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