Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but molecular mechanisms underlying anesthetic action remain debatable. We found that ELIC, a pLGIC from Erwinia chrysanthemi, can be functionally inhibited by isoflurane and other anesthetics. Structures of ELIC co-cr...

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Publicado en:Sci Rep
Autores principales: Chen, Qiang, Kinde, Monica N., Arjunan, Palaniappa, Wells, Marta M., Cohen, Aina E., Xu, Yan, Tang, Pei
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561908/
https://ncbi.nlm.nih.gov/pubmed/26346220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13833
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