Ca(2+) toxicity due to reverse Na(+)/Ca(2+) exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation

Gain-of-function missense mutations in voltage-gated sodium channel Nav1.7 have been linked to small-fiber neuropathy, which is characterized by burning pain, dysautonomia and a loss of intraepidermal nerve fibers. However, the mechanistic cascades linking Nav1.7 mutations to axonal degeneration are...

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Bibliographic Details
Published in:J Neurophysiol
Main Authors: Estacion, M., Vohra, B. P. S, Liu, S., Hoeijmakers, J., Faber, C. G., Merkies, I. S. J., Lauria, G., Black, J. A., Waxman, S. G.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Nervous System Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561630/
https://ncbi.nlm.nih.gov/pubmed/26156380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00195.2015
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