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Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

BACKGROUND: Sodium channel Nav1.7 has emerged as a target of considerable interest in pain research, since loss-of-function mutations in SCN9A, the gene that encodes Nav1.7, are associated with a syndrome of congenital insensitivity to pain, gain-of-function mutations are linked to the debiliting ch...

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Detalhes bibliográficos
Main Authors: Black, Joel A, Frézel, Noémie, Dib-Hajj, Sulayman D, Waxman, Stephen G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517774/
https://ncbi.nlm.nih.gov/pubmed/23134641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-82
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