Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype

Lignende værker

• Effects of ranolazine on wild-type and mutant hNa(v)1.7 channels and on DRG neuron excitability
  af: Estacion, Mark, et al.
  Udgivet: (2010)
• Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn
  af: Black, Joel A, et al.
  Udgivet: (2012)
• Paroxysmal extreme pain disorder M1627K mutation in human Na(v)1.7 renders DRG neurons hyperexcitable
  af: Dib-Hajj, Sulayman D, et al.
  Udgivet: (2008)
• Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons
  af: Han, Chongyang, et al.
  Udgivet: (2015)
• A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain
  af: Huang, Jianying, et al.
  Udgivet: (2019)