Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that APOL1 induces...

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Publicado en:Nat Commun
Autores principales: Vanwalleghem, Gilles, Fontaine, Frédéric, Lecordier, Laurence, Tebabi, Patricia, Klewe, Kristoffer, Nolan, Derek P., Yamaryo-Botté, Yoshiki, Botté, Cyrille, Kremer, Anneke, Burkard, Gabriela Schumann, Rassow, Joachim, Roditi, Isabel, Pérez-Morga, David, Pays, Etienne
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560804/
https://ncbi.nlm.nih.gov/pubmed/26307671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9078
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