Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that APOL1 induces...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Vanwalleghem, Gilles, Fontaine, Frédéric, Lecordier, Laurence, Tebabi, Patricia, Klewe, Kristoffer, Nolan, Derek P., Yamaryo-Botté, Yoshiki, Botté, Cyrille, Kremer, Anneke, Burkard, Gabriela Schumann, Rassow, Joachim, Roditi, Isabel, Pérez-Morga, David, Pays, Etienne
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560804/
https://ncbi.nlm.nih.gov/pubmed/26307671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9078
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