Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1

Humans resist infection by the African parasite Trypanosoma brucei owing to the trypanolytic activity of the serum apolipoprotein L1 (APOL1). Following uptake by endocytosis in the parasite, APOL1 forms pores in endolysosomal membranes and triggers lysosome swelling. Here we show that APOL1 induces...

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Foilsithe in:Nat Commun
Main Authors: Vanwalleghem, Gilles, Fontaine, Frédéric, Lecordier, Laurence, Tebabi, Patricia, Klewe, Kristoffer, Nolan, Derek P., Yamaryo-Botté, Yoshiki, Botté, Cyrille, Kremer, Anneke, Burkard, Gabriela Schumann, Rassow, Joachim, Roditi, Isabel, Pérez-Morga, David, Pays, Etienne
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Pub. Group 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560804/
https://ncbi.nlm.nih.gov/pubmed/26307671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9078
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