A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Metastasis is the leading cause of death in osteosarcoma patients, the most common pediatric bone malignancy. We conducted a multi-stage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determine whether germline genetic variation contributes to r...

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Izdano u:Cancer Discov
Glavni autori: Mirabello, Lisa, Koster, Roelof, Moriarity, Branden S., Spector, Logan G., Meltzer, Paul S., Gary, Joy, Machiela, Mitchell J., Pankratz, Nathan, Panagiotou, Orestis A., Largaespada, David, Wang, Zhaoming, Gastier-Foster, Julie M., Gorlick, Richard, Khanna, Chand, de Toledo, Silvia Regina Caminada, Petrilli, Antonio S., Patiño-Garcia, Ana, Sierrasesúmaga, Luis, Lecanda, Fernando, Andrulis, Irene L., Wunder, Jay S., Gokgoz, Nalan, Serra, Massimo, Hattinger, Claudia, Picci, Piero, Scotlandi, Katia, Flanagan, Adrienne M., Tirabosco, Roberto, Amary, Maria Fernanda, Halai, Dina, Ballinger, Mandy L., Thomas, David M., Davis, Sean, Barkauskas, Donald A., Marina, Neyssa, Helman, Lee, Otto, George M., Becklin, Kelsie L., Wolf, Natalie K., Weg, Madison T., Tucker, Margaret, Wacholder, Sholom, Fraumeni, Joseph F., Caporaso, Neil E., Boland, Joseph F., Hicks, Belynda D., Vogt, Aurelie, Burdett, Laurie, Yeager, Meredith, Hoover, Robert N., Chanock, Stephen J., Savage, Sharon A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560660/
https://ncbi.nlm.nih.gov/pubmed/26084801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0125
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