A genome-wide scan identifies variants in NFIB associated with metastasis in patients with osteosarcoma

Metastasis is the leading cause of death in osteosarcoma patients, the most common pediatric bone malignancy. We conducted a multi-stage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determine whether germline genetic variation contributes to r...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Mirabello, Lisa, Koster, Roelof, Moriarity, Branden S., Spector, Logan G., Meltzer, Paul S., Gary, Joy, Machiela, Mitchell J., Pankratz, Nathan, Panagiotou, Orestis A., Largaespada, David, Wang, Zhaoming, Gastier-Foster, Julie M., Gorlick, Richard, Khanna, Chand, de Toledo, Silvia Regina Caminada, Petrilli, Antonio S., Patiño-Garcia, Ana, Sierrasesúmaga, Luis, Lecanda, Fernando, Andrulis, Irene L., Wunder, Jay S., Gokgoz, Nalan, Serra, Massimo, Hattinger, Claudia, Picci, Piero, Scotlandi, Katia, Flanagan, Adrienne M., Tirabosco, Roberto, Amary, Maria Fernanda, Halai, Dina, Ballinger, Mandy L., Thomas, David M., Davis, Sean, Barkauskas, Donald A., Marina, Neyssa, Helman, Lee, Otto, George M., Becklin, Kelsie L., Wolf, Natalie K., Weg, Madison T., Tucker, Margaret, Wacholder, Sholom, Fraumeni, Joseph F., Caporaso, Neil E., Boland, Joseph F., Hicks, Belynda D., Vogt, Aurelie, Burdett, Laurie, Yeager, Meredith, Hoover, Robert N., Chanock, Stephen J., Savage, Sharon A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560660/
https://ncbi.nlm.nih.gov/pubmed/26084801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0125
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