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Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate

We recently described a new, live-attenuated vaccine candidate for chikungunya (CHIK) fever, CHIKV/IRES. This vaccine was shown to be well attenuated, immunogenic and efficacious in protecting against CHIK virus (CHIKV) challenge of mice and nonhuman primates. To further evaluate its preclinical saf...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Plante, Kenneth S, Rossi, Shannan L., Bergren, Nicholas A., Seymour, Robert L., Weaver, Scott C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560411/
https://ncbi.nlm.nih.gov/pubmed/26340754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004007
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